The Genetic Evolution of Melanoma from Precursor Lesions
Author(s) -
A. Hunter Shain,
Iwei Yeh,
Ivanka Kovalyshyn,
Aravindhan Sriharan,
Eric Talevich,
Alexander Gag,
Reinhard Dummer,
Jeffrey P. North,
Laura B. Pincus,
Beth S. Ruben,
William Rickaby,
Corrado D’Arrigo,
Alistair Robson,
Boris C. Bastian
Publication year - 2015
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1502583
Subject(s) - cdkn2a , neuroblastoma ras viral oncogene homolog , melanoma , pten , gnaq , cancer research , genetic heterogeneity , mutation , biology , point mutation , gene , cancer , carcinogenesis , v600e , epidermodysplasia verruciformis , medicine , genetics , phenotype , kras , pi3k/akt/mtor pathway , signal transduction , virus
The pathogenic mutations in melanoma have been largely catalogued; however, the order of their occurrence is not known.
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