High HLA-DP Expression and Graft-versus-Host Disease | Zendy

Effie W. Petersdorf | Zendy; Mari Malkki | Zendy; Colm Ó’hUigín | Zendy; Mary Carrington | Zendy; Ted Gooley | Zendy; Michael Haagenson | Zendy; Mary M. Horowitz | Zendy; Stephen R. Spellman | Zendy; Tao Wang | Zendy; Philip A. Stevenson | Zendy

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High HLA-DP Expression and Graft-versus-Host Disease

Author(s) -

Effie W. Petersdorf,

Mari Malkki,

Colm Ó’hUigín,

Mary Carrington,

Ted Gooley,

Michael Haagenson,

Mary M. Horowitz,

Stephen R. Spellman,

Tao Wang,

Philip A. Stevenson

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1500140

Subject(s) - human leukocyte antigen , allele , hazard ratio , immunology , graft versus host disease , disease , hematopoietic stem cell transplantation , transplantation , hla b antigens , histocompatibility , medicine , biology , confidence interval , genetics , antigen , gene

Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is higher when the recipient and donor are HLA-DPB1-mismatched, but the mechanisms leading to GVHD are unknown. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. We tested the hypothesis that the GVHD risk correlates with the rs9277534 allele linked to the mismatched HLA-DPB1 in the recipient.

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