Effect of Mutation Order on Myeloproliferative Neoplasms | Zendy

Christina A. Ortmann | Zendy; David G. Kent | Zendy; Jyoti Nangalia | Zendy; Yvonne Silber | Zendy; David C. Wedge | Zendy; Jacob Grinfeld | Zendy; E. Joanna Baxter | Zendy; Charles Massie | Zendy; Elli Papaemmanuil | Zendy; Suraj Me | Zendy; Anna L. Godfrey | Zendy; D. Dimitropoulou | Zendy; Paola Guglielmelli | Zendy; Beatríz Bellosillo | Zendy; Carles Besses | Zendy; Konstanze Döhner | Zendy; Claire Harrison | Zendy; George S. Vassiliou | Zendy; Alessandro M. Vannucchi | Zendy; Peter J. Campbell | Zendy; Anthony R. Green | Zendy

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Effect of Mutation Order on Myeloproliferative Neoplasms

Author(s) -

Christina A. Ortmann,

David G. Kent,

Jyoti Nangalia,

Yvonne Silber,

David C. Wedge,

Jacob Grinfeld,

E. Joanna Baxter,

Charles Massie,

Elli Papaemmanuil,

Suraj Me,

Anna L. Godfrey,

D. Dimitropoulou,

Paola Guglielmelli,

Beatríz Bellosillo,

Carles Besses,

Konstanze Döhner,

Claire Harrison,

George S. Vassiliou,

Alessandro M. Vannucchi,

Peter J. Campbell,

Anthony R. Green

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1412098

Subject(s) - mutation , myeloproliferative neoplasm , progenitor cell , janus kinase 2 , haematopoiesis , essential thrombocythemia , cancer research , germline mutation , polycythemia vera , stem cell , clonogenic assay , medicine , biology , myeloid , immunology , myelofibrosis , genetics , cell culture , bone marrow , gene

Cancers result from the accumulation of somatic mutations, and their properties are thought to reflect the sum of these mutations. However, little is known about the effect of the order in which mutations are acquired.

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