Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme | Zendy

Norbert Krug | Zendy; Jens M. Hohlfeld | Zendy; AnneMarie Kirsten | Zendy; Oliver Kornmann | Zendy; Kai Michael Beeh | Zendy; Dominik Kappeler | Zendy; Stephanie Korn | Zendy; Stanislav Ignatenko | Zendy; Wolfgang Timmer | Zendy; Cordelia Rogon | Zendy; Jana Zeitvogel | Zendy; Nan Zhang | Zendy; Joachim Bille | Zendy; Ursula Homburg | Zendy; Agnieszka Turowska | Zendy; Claus Bachert | Zendy; Thomas Werfel | Zendy; Roland Buhl | Zendy; Jonas Renz | Zendy; Holger Garn | Zendy; Harald Renz | Zendy

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Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

Author(s) -

Norbert Krug,

Jens M. Hohlfeld,

AnneMarie Kirsten,

Oliver Kornmann,

Kai Michael Beeh,

Dominik Kappeler,

Stephanie Korn,

Stanislav Ignatenko,

Wolfgang Timmer,

Cordelia Rogon,

Jana Zeitvogel,

Nan Zhang,

Joachim Bille,

Ursula Homburg,

Agnieszka Turowska,

Claus Bachert,

Thomas Werfel,

Roland Buhl,

Jonas Renz,

Holger Garn,

Harald Renz

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1411776

Subject(s) - medicine , asthma , placebo , provocation test , immunology , allergen , eosinophil , eosinophilia , inhalation , fexofenadine , area under the curve , eosinophil cationic protein , gata3 , sputum , bronchoconstriction , allergy , pharmacology , anesthesia , pathology , tuberculosis , alternative medicine , biochemistry , chemistry , transcription factor , gene

The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of GATA3, an important transcription factor of the Th2 pathway, may be beneficial. We evaluated the safety and efficacy of SB010, a novel DNA enzyme (DNAzyme) that is able to cleave and inactivate GATA3 messenger RNA (mRNA).

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