Clinical Care of Two Patients with Ebola Virus Disease in the United States | Zendy

G. Marshall Lyon | Zendy; Aneesh K. Mehta | Zendy; Jay B. Varkey | Zendy; Kent Brantly | Zendy; Lance Plyler | Zendy; Anita K. McElroy | Zendy; Colleen S. Kraft | Zendy; Jonathan S. Towner | Zendy; Christina F. Spiropoulou | Zendy; Ute Ströher | Zendy; Timothy M. Uyeki | Zendy; Bruce S. Ribner | Zendy

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Clinical Care of Two Patients with Ebola Virus Disease in the United States

Author(s) -

G. Marshall Lyon,

Aneesh K. Mehta,

Jay B. Varkey,

Kent Brantly,

Lance Plyler,

Anita K. McElroy,

Colleen S. Kraft,

Jonathan S. Towner,

Christina F. Spiropoulou,

Ute Ströher,

Timothy M. Uyeki,

Bruce S. Ribner

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1409838

Subject(s) - medicine , ebola virus , outbreak , concomitant , malaria , disease , emergency medicine , intensive care medicine , virus , pediatrics , virology , immunology

West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.

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