HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events
Author(s) -
Anand Rohatgi,
Amit Khera,
Jarett D. Berry,
Edward G. Givens,
Colby Ayers,
Kyle E. Wedin,
Ian J. Neeland,
Ivan S. Yuhanna,
Daniel Rader,
James A. de Lemos,
Philip W. Shaul
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1409065
Subject(s) - medicine , cholesterol , efflux , reverse cholesterol transport , risk factor , high density lipoprotein , population , cohort , lipoprotein , endocrinology , environmental health , biology , biochemistry
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of HDL to accept cholesterol from macrophages, which is a key step in reverse cholesterol transport. We investigated the epidemiology of cholesterol efflux capacity and its association with incident atherosclerotic cardiovascular disease outcomes in a large, multiethnic population cohort.
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