Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Author(s) -
Siddhartha Jaiswal,
Pierre Fontanillas,
Jason Flannick,
Alisa K. Manning,
Peter Grauman,
Brenton G. Mar,
R. Coleman Lindsley,
Craig H. Mermel,
Noël P. Burtt,
Alejandro Chavez,
John M. Higgins,
Vladislav Moltchanov,
Frank C. Kuo,
Michael Kluk,
Brian E. Henderson,
Leena Kinnunen,
Heikki A. Koistinen,
Claes Ladenvall,
Gad Getz,
Adolfo Correa,
Benjamin F. Banahan,
Stacey Gabriel,
Sekar Kathiresan,
Heather M. Stringham,
Mark I. McCarthy,
Michael Boehnke,
Jaakko Tuomilehto,
Christopher Haiman,
Leif Groop,
Gil Atzmon,
James G. Wilson,
Doneuberg,
David Altshuler,
Benjamin L. Ebert
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1408617
Subject(s) - somatic cell , haematopoiesis , hematologic neoplasms , hematologic disorders , incidence (geometry) , somatic evolution in cancer , hematology , medicine , germline mutation , mutation , oncology , immunology , cancer , gene , biology , genetics , stem cell , physics , optics
The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to have hematologic disorders.
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