Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease | Zendy

Giovanni Monteleone | Zendy; Markus F. Neurath | Zendy; Sandro Ardizzone | Zendy; Antonio Di Sabatino | Zendy; Massimo Claudio Fantini | Zendy; Fabiana Castiglione | Zendy; Maria Lia Scribano | Zendy; Alessandro Armuzzi | Zendy; Flavio Caprioli | Zendy; Giacomo Carlo Sturniolo | Zendy; Francesca Rogai | Zendy; M. Vecchi | Zendy; Raja Atreya | Zendy; Fabrizio Bossa | Zendy; S. Onali | Zendy; Maria Fichera | Zendy; Gino Roberto Corazza | Zendy; Livia Biancone | Zendy; Vincenzo Savarino | Zendy; Roberta Pica | Zendy; Ambrogio Orlando | Zendy; Francesco Pallone | Zendy

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Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

Author(s) -

Giovanni Monteleone,

Markus F. Neurath,

Sandro Ardizzone,

Antonio Di Sabatino,

Massimo Claudio Fantini,

Fabiana Castiglione,

Maria Lia Scribano,

Alessandro Armuzzi,

Flavio Caprioli,

Giacomo Carlo Sturniolo,

Francesca Rogai,

M. Vecchi,

Raja Atreya,

Fabrizio Bossa,

S. Onali,

Maria Fichera,

Gino Roberto Corazza,

Livia Biancone,

Vincenzo Savarino,

Roberta Pica,

Ambrogio Orlando,

Francesco Pallone

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1407250

Subject(s) - crohn's disease , medicine , oligonucleotide , cytokine , transforming growth factor , inflammation , crohn disease , disease , immunology , cancer research , gene , biology , biochemistry

Crohn's disease-related inflammation is characterized by reduced activity of the immunosuppressive cytokine transforming growth factor β1 (TGF-β1) due to high levels of SMAD7, an inhibitor of TGF-β1 signaling. Preclinical studies and a phase 1 study have shown that an oral SMAD7 antisense oligonucleotide, mongersen, targets ileal and colonic SMAD7.

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