One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers | Zendy

John E. Wagner | Zendy; Mary Eapen | Zendy; Shelly Carter | Zendy; Yanli Wang | Zendy; Kirk R. Schultz | Zendy; Donna A. Wall | Zendy; Nancy Bunin | Zendy; Colleen Delaney | Zendy; Paul R. Haut | Zendy; David M. Margolis | Zendy; Edward Peres | Zendy; Michael R. Verneris | Zendy; Mark C. Walters | Zendy; Mary M. Horowitz | Zendy; Joanne Kurtzberg | Zendy

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One-Unit versus Two-Unit Cord-Blood Transplantation for Hematologic Cancers

Author(s) -

John E. Wagner,

Mary Eapen,

Shelly Carter,

Yanli Wang,

Kirk R. Schultz,

Donna A. Wall,

Nancy Bunin,

Colleen Delaney,

Paul R. Haut,

David M. Margolis,

Edward Peres,

Michael R. Verneris,

Mark C. Walters,

Mary M. Horowitz,

Joanne Kurtzberg

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1405584

Subject(s) - medicine , cord blood , transplantation , umbilical cord , hematopoietic stem cell transplantation , umbilical cord blood transplantation , surgery , gastroenterology , immunology

Umbilical-cord blood has been used as the source of hematopoietic stem cells in an estimated 30,000 transplants. The limited number of hematopoietic cells in a single cord-blood unit prevents its use in recipients with larger body mass and results in delayed hematopoietic recovery and higher mortality. Therefore, we hypothesized that the greater numbers of hematopoietic cells in two units of cord blood would be associated with improved outcomes after transplantation.

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