The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans | Zendy

Candida Cristina Quarta | Zendy; Joel N. Buxbaum | Zendy; Amil M. Shah | Zendy; Rodney H. Falk | Zendy; Brian Claggett | Zendy; Dalane W. Kitzman | Zendy; Thomas H. Mosley | Zendy; Kenneth R. Butler | Zendy; Eric Boerwinkle | Zendy; Scott D. Solomon | Zendy

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The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans

Author(s) -

Candida Cristina Quarta,

Joel N. Buxbaum,

Amil M. Shah,

Rodney H. Falk,

Brian Claggett,

Dalane W. Kitzman,

Thomas H. Mosley,

Kenneth R. Butler,

Eric Boerwinkle,

Scott D. Solomon

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1404852

Subject(s) - transthyretin , medicine , valine , cardiomyopathy , amyloid (mycology) , isoleucine , heart failure , endocrinology , genetics , amino acid , pathology , leucine , biology

Approximately 4% of black Americans carry a valine-to-isoleucine substitution (V122I) in the transthyretin protein, which has been associated with late-onset restrictive amyloid cardiomyopathy and increased risks of death and heart failure.

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