Prions in the Urine of Patients with Variant Creutzfeldt–Jakob Disease | Zendy

Fabio Moda | Zendy; Pierluigi Gambetti | Zendy; Silvio Notari | Zendy; Luis ConchaMarambio | Zendy; Marcella Catania | Zendy; Kyung-Won Park | Zendy; Emanuela Maderna | Zendy; Silvia Suardi | Zendy; Stéphane Haı̈k | Zendy; J.-P. Brandel | Zendy; James W. Ironside | Zendy; Richard Knight | Zendy; Fabrizio Tagliavini | Zendy; Claudio Soto | Zendy

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Prions in the Urine of Patients with Variant Creutzfeldt–Jakob Disease

Author(s) -

Fabio Moda,

Pierluigi Gambetti,

Silvio Notari,

Luis ConchaMarambio,

Marcella Catania,

Kyung-Won Park,

Emanuela Maderna,

Silvia Suardi,

Stéphane Haı̈k,

J.-P. Brandel,

James W. Ironside,

Richard Knight,

Fabrizio Tagliavini,

Claudio Soto

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1404401

Subject(s) - urine , medicine , disease , prion protein , virology , bovine spongiform encephalopathy , creutzfeldt jakob syndrome , confidence interval , transmission (telecommunications) , pathology , gastroenterology , electrical engineering , engineering

Prions, the infectious agents responsible for transmissible spongiform encephalopathies, consist mainly of the misfolded prion protein (PrP(Sc)). The unique mechanism of transmission and the appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to consumption of prion-contaminated cattle meat, have raised concerns about public health. Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluids from people in whom the disease is silently incubating.

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