Open AccessTwo Clinical Phenotypes in Polycythemia Vera
Author(s) -
Jerry L. Spivak,
Michael Considine,
Donna M. Williams,
C. Conover Talbot,
Ophelia Rogers,
Alison R. Moliterno,
Chunfa Jie,
Michael F. Ochs
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1403141
Subject(s) - polycythemia vera , medicine , janus kinase 2 , phenotype , haematopoiesis , mutation , cd34 , genetics , cancer research , stem cell , immunology , biology , gene , receptor
Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown.
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