Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia | Zendy

Kathryn G. Roberts | Zendy; Yongjin Li | Zendy; Debbie Payne-Turner | Zendy; Richard C. Harvey | Zendy; YungLi Yang | Zendy; Deqing Pei | Zendy; Kelly McCastlain | Zendy; Li Ding | Zendy; Charles Lu | Zendy; Guangchun Song | Zendy; Jing Ma | Zendy; Jared Becksfort | Zendy; Michael Rusch | Zendy; Shann-Ching Chen | Zendy; John Easton | Zendy; Jinjun Cheng | Zendy; Kristy Boggs | Zendy; Natalia Santiago-Morales | Zendy; Ilaria Iacobucci | Zendy; Robert S. Fulton | Zendy; Ji Wen | Zendy; Marcus Valentine | Zendy; Cheng Cheng | Zendy; Steven W. Paugh | Zendy; Meenakshi Devidas | Zendy; IMing Chen | Zendy; Shalini C. Reshmi | Zendy; Amy Smith | Zendy; Erin Hedlund | Zendy; Pankaj Gupta | Zendy; Panduka Nagahawatte | Zendy; Gang Wu | Zendy; Xiang Chen | Zendy; Donald Yergeau | Zendy; Bhavin Vadodaria | Zendy; Heather L. Mulder | Zendy; Naomi J. Winick | Zendy; Eric Larsen | Zendy; William L. Carroll | Zendy; Nyla A. Heerema | Zendy; Andrew J. Carroll | Zendy; Guy H. Grayson | Zendy; Sarah K. Tasian | Zendy; Andrew S. Moore | Zendy; Frank Keller | Zendy; Melissa FreiJones | Zendy; James A. Whitlock | Zendy; Elizabeth A. Raetz | Zendy; Deborah L. White | Zendy; Timothy P. Hughes | Zendy; Jaime M. Guidry Auvil | Zendy; Malcolm A. Smith | Zendy; Guido Marcucci | Zendy; Clara D. Bloomfield | Zendy; Krzysztof Mrózek | Zendy; Jessica Kohlschmidt | Zendy; Wendy Stock | Zendy; Steven M. Kornblau | Zendy; Marina Konopleva | Zendy; Elisabeth Paietta | Zendy; ChingHon Pui | Zendy; Sima Jeha | Zendy; Mary V. Relling | Zendy; William E. Evans | Zendy; Daniela S. Gerhard | Zendy; Julie M. Gastier-Foster | Zendy; Elaine R. Mardis | Zendy; Richard K. Wilson | Zendy; Mig L. Loh | Zendy; James R. Downing | Zendy; Stephen P. Hunger | Zendy; Cheryl L. Willman | Zendy; Jinghui Zhang | Zendy; Charles G. Mullighan | Zendy

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Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

Author(s) -

Kathryn G. Roberts,

Yongjin Li,

Debbie Payne-Turner,

Richard C. Harvey,

YungLi Yang,

Deqing Pei,

Kelly McCastlain,

Li Ding,

Charles Lu,

Guangchun Song,

Jing Ma,

Jared Becksfort,

Michael Rusch,

Shann-Ching Chen,

John Easton,

Jinjun Cheng,

Kristy Boggs,

Natalia Santiago-Morales,

Ilaria Iacobucci,

Robert S. Fulton,

Ji Wen,

Marcus Valentine,

Cheng Cheng,

Steven W. Paugh,

Meenakshi Devidas,

IMing Chen,

Shalini C. Reshmi,

Amy Smith,

Erin Hedlund,

Pankaj Gupta,

Panduka Nagahawatte,

Gang Wu,

Xiang Chen,

Donald Yergeau,

Bhavin Vadodaria,

Heather L. Mulder,

Naomi J. Winick,

Eric Larsen,

William L. Carroll,

Nyla A. Heerema,

Andrew J. Carroll,

Guy H. Grayson,

Sarah K. Tasian,

Andrew S. Moore,

Frank Keller,

Melissa FreiJones,

James A. Whitlock,

Elizabeth A. Raetz,

Deborah L. White,

Timothy P. Hughes,

Jaime M. Guidry Auvil,

Malcolm A. Smith,

Guido Marcucci,

Clara D. Bloomfield,

Krzysztof Mrózek,

Jessica Kohlschmidt,

Wendy Stock,

Steven M. Kornblau,

Marina Konopleva,

Elisabeth Paietta,

ChingHon Pui,

Sima Jeha,

Mary V. Relling,

William E. Evans,

Daniela S. Gerhard,

Julie M. Gastier-Foster,

Elaine R. Mardis,

Richard K. Wilson,

Mig L. Loh,

James R. Downing,

Stephen P. Hunger,

Cheryl L. Willman,

Jinghui Zhang,

Charles G. Mullighan

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1403088

Subject(s) - lymphoblastic leukemia , tyrosine kinase , cancer research , philadelphia chromosome , gene , leukemia , abl , kinase , medicine , tyrosine kinase inhibitor , biology , chromosomal translocation , genetics , signal transduction , cancer

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.

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