Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD | Zendy

Gerard J. Criner | Zendy; John E. Connett | Zendy; Shawn D. Aaron | Zendy; Richard Albert | Zendy; William C. Bailey | Zendy; Richard Casaburi | Zendy; John A. Cooper | Zendy; Jeffrey L. Curtis | Zendy; Mark T. Dransfield | Zendy; MeiLan K. Han | Zendy; Barry J. Make | Zendy; Nathaniel Marchetti | Zendy; Fernando J. Martínez | Zendy; Dennis E. Niewoehner | Zendy; Paul D. Scanlon | Zendy; Frank C. Sciurba | Zendy; Steven M. Scharf | Zendy; Don D. Sin | Zendy; Helen Voelker | Zendy; George R. Washko | Zendy; Prescott G. Woodruff | Zendy; Stephen C. Lazarus | Zendy

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Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD

Author(s) -

Gerard J. Criner,

John E. Connett,

Shawn D. Aaron,

Richard Albert,

William C. Bailey,

Richard Casaburi,

John A. Cooper,

Jeffrey L. Curtis,

Mark T. Dransfield,

MeiLan K. Han,

Barry J. Make,

Nathaniel Marchetti,

Fernando J. Martínez,

Dennis E. Niewoehner,

Paul D. Scanlon,

Frank C. Sciurba,

Steven M. Scharf,

Don D. Sin,

Helen Voelker,

George R. Washko,

Prescott G. Woodruff,

Stephen C. Lazarus

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1403086

Subject(s) - medicine , copd , simvastatin , exacerbation , randomized controlled trial , placebo , diabetes mellitus , vital capacity , physical therapy , lung , diffusing capacity , lung function , alternative medicine , pathology , endocrinology

Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied the efficacy of simvastatin in preventing exacerbations in a large, multicenter, randomized trial.

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