Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease | Zendy

Vicente E. Torres | Zendy; Kaleab Z. Abebe | Zendy; Arlene B. Chapman | Zendy; Robert W. Schrier | Zendy; William E. Braun | Zendy; Theodore I. Steinman | Zendy; Franz T. Winklhofer | Zendy; Godela Brosnahan | Zendy; Peter G. Czarnecki | Zendy; Marie C. Hogan | Zendy; Dana C. Miskulin | Zendy; Frederic F. Rahbari-Oskoui | Zendy; Jared J. Grantham | Zendy; Peter C. Harris | Zendy; Michael F. Flessner | Zendy; Charity G. Moore | Zendy; Ronald D. Perrone | Zendy

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Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease

Author(s) -

Vicente E. Torres,

Kaleab Z. Abebe,

Arlene B. Chapman,

Robert W. Schrier,

William E. Braun,

Theodore I. Steinman,

Franz T. Winklhofer,

Godela Brosnahan,

Peter G. Czarnecki,

Marie C. Hogan,

Dana C. Miskulin,

Frederic F. Rahbari-Oskoui,

Jared J. Grantham,

Peter C. Harris,

Michael F. Flessner,

Charity G. Moore,

Ronald D. Perrone

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1402686

Subject(s) - blockade , medicine , renin–angiotensin system , polycystic kidney disease , polycystic kidney , autosomal dominant polycystic kidney disease , disease , cardiology , kidney disease , receptor , blood pressure

Hypertension develops early in patients with autosomal dominant polycystic kidney disease (ADPKD) and is associated with disease progression. The renin-angiotensin-aldosterone system (RAAS) is implicated in the pathogenesis of hypertension in patients with ADPKD. Dual blockade of the RAAS may circumvent compensatory mechanisms that limit the efficacy of monotherapy with an angiotensin-converting-enzyme (ACE) inhibitor or angiotensin II-receptor blocker (ARB).

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