Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas | Zendy

Daniel J. Brat | Zendy; Roel G.W. Verhaak | Zendy; Kenneth D. Aldape | Zendy; W. K. Alfred Yung | Zendy; Sofie R. Salama | Zendy; Lee Cooper | Zendy; Esther Rheinbay | Zendy; C. Ryan Miller | Zendy; Mark Vitucci | Zendy; Olena Morozova | Zendy; A. Gordon Robertson | Zendy; Houtan Noushmehr | Zendy; Peter W. Laird | Zendy; Andrew D. Cherniack | Zendy; Rehan Akbani | Zendy; Jason T. Huse | Zendy; Giovanni Ciriello | Zendy; Laila Poisson | Zendy; Jill S. BarnholtzSloan | Zendy; Mitchel S. Berger | Zendy; Cameron Brennan | Zendy; Rivka R. Colen | Zendy; Howard Colman | Zendy; Adam E. Flanders | Zendy; Caterina Giannini | Zendy; Mia Grifford | Zendy; Antonio Iavarone | Zendy; Rajan Jain | Zendy; Isaac Joseph | Zendy; Jaegil Kim | Zendy; L. Sylvia | Zendy; Tom Mikkelsen | Zendy; Bradley A. Murray | Zendy; Brian Patrick O’Neill | Zendy; Lior Pachter | Zendy; D. Williams Parsons | Zendy; Carrie Sougnez | Zendy; Erik P. Sulman | Zendy; Scott R. VandenBerg | Zendy; Erwin G. Van Meir | Zendy; Andreas von Deimling | Zendy; Hailei Zhang | Zendy; Daniel Crain | Zendy; Kevin Lau | Zendy; David Mallery | Zendy; Scott Morris | Zendy; Joseph Paulauskis | Zendy; Robert Penny | Zendy; Troy Shelton | Zendy; Mark E. Sherman | Zendy; Peggy Yena | Zendy; Aaron Black | Zendy; Jay Bowen | Zendy; Katie Dicostanzo | Zendy; Julie M. GastierFoster | Zendy; Kristen Leraas | Zendy; Tara M. Lichtenberg | Zendy; Christopher R. Pierson | Zendy; Nilsa C. Ramirez | Zendy; Cynthia Taylor | Zendy; Stephanie Weaver | Zendy; Lisa Wise | Zendy; Erik Zmuda | Zendy; Tanja M. Davidsen | Zendy; John A. Demchok | Zendy; Greg Eley | Zendy; Martin L. Ferguson | Zendy; Carolyn M. Hutter | Zendy; Kenna Shaw | Zendy; Bradley A. Ozenberger | Zendy; Margi Sheth | Zendy; Heidi J. Sofia | Zendy; Roy Tarnuzzer | Zendy; Linghua Wang | Zendy; Liming Yang | Zendy; Jean C. Zenklusen | Zendy; Brenda Ayala | Zendy; Julien Baboud | Zendy; Sudha Chudamani | Zendy; Mark A. Jensen | Zendy; Jia Liu | Zendy; Todd Pihl | Zendy; Rohini Raman | Zendy; Yunhu Wan | Zendy; Ye Wu | Zendy; Adrian Ally | Zendy; J. Todd Auman | Zendy; Miruna Balasundaram | Zendy; Saianand Balu | Zendy; Stephen B. Baylin | Zendy; Rameen Beroukhim | Zendy; Arnoud Boot | Zendy; Reanne Bowlby | Zendy; Christopher A. Bristow | Zendy; Denise Brooks | Zendy; Yaron S.N. Butterfield | Zendy; Rebecca Carlsen | Zendy; Scott L. Carter | Zendy; Lynda Chin | Zendy; Andy Chu | Zendy; Eric Chuah | Zendy; Kristian Cibulskis | Zendy; Amanda Clarke | Zendy; Simon G. Coetzee | Zendy; Noreen Dhalla | Zendy; Timothy R. Fennell | Zendy; Sheila Fisher | Zendy; Stacey Gabriel | Zendy; Gad Getz | Zendy; Richard A. Gibbs | Zendy; Ranabir Guin | Zendy; Angela Hadjipanayis | Zendy; D. Neil Hayes | Zendy; Toshinori Hinoue | Zendy; Katherine A. Hoadley | Zendy; Robert A. Holt | Zendy; Alan P. Hoyle | Zendy; Joshua M. Stuart | Zendy; Steven J.M. Jones | Zendy; Corbin D. Jones | Zendy; Raju Kucherlapati | Zendy; Phillip H. Lai | Zendy; Eric S. Lander | Zendy; Semin Lee | Zendy; Lee Lichtenstein | Zendy; Yussanne Ma | Zendy; Dennis T. Maglinte | Zendy; Harshad S. Mahadeshwar | Zendy; Marco A. Marra | Zendy; Michael Mayo | Zendy; Shaowu Meng | Zendy; Matthew Meyerson | Zendy; Piotr A. Mieczkowski | Zendy; Richard A. Moore | Zendy; Lisle E. Mose | Zendy; Andrew J. Mungall | Zendy; Angeliki Pantazi | Zendy; Michael Parfenov | Zendy; Peter J. Park | Zendy; Joel S. Parker | Zendy; Charles M. Perou | Zendy; Alexei Protopopov | Zendy; Xiaojia Ren | Zendy; Jeffrey Roach | Zendy; Thaís S. Sabedot | Zendy; Jacqueline E. Schein | Zendy; Steven E. Schumacher | Zendy; Jonathan G. Seidman | Zendy; Sahil Seth | Zendy; Hui Shen | Zendy; Janae V. Simons | Zendy; Payal Sipahimalani | Zendy; Matthew G. Soloway | Zendy; Xingzhi Song | Zendy; Huandong Sun | Zendy; Barbara Tabak | Zendy; Angela Tam | Zendy; Donghui Tan | Zendy; Jiabin Tang | Zendy; Nina Thiessen | Zendy; Timothy J. Triche | Zendy; David Van Den Berg | Zendy; Umadevi Veluvolu | Zendy; Stephen C. Waring | Zendy; Daniel J. Weisenberger | Zendy; Matthew D. Wilkerson | Zendy; Tina Wong | Zendy; Junyuan Wu | Zendy; Xi Liu | Zendy; Andrew Wei Xu | Zendy; Lixing Yang | Zendy; Travis Zack | Zendy; Jianhua Zhang | Zendy; Bülent Arman Aksoy | Zendy; Harindra Arachchi | Zendy; Chris Benz | Zendy; Brady Bernard | Zendy; Daniel E. Carlin | Zendy; Juok Cho | Zendy; Daniel DiCara | Zendy; Scott Frazer | Zendy; Gregory N. Fuller | Zendy; Jian Jiong Gao | Zendy; Nils Gehlenborg | Zendy; David Haussler | Zendy; David I. Heiman | Zendy; Lisa Iype | Zendy; Anders J. Skanderup | Zendy; Zhenlin Ju | Zendy; Sol Katzman | Zendy; Hoon Kim | Zendy; Theo Knijnenburg | Zendy; Richard Kreisberg | Zendy; Michael S. Lawrence | Zendy; William Lee | Zendy; Kalle Lein | Zendy; Pei Lin | Zendy; Shiyun Ling | Zendy; Wenbin Liu | Zendy; Yingchun Liu | Zendy; Yuexin Liu | Zendy; Yiling Lu | Zendy; Gordon B. Mills | Zendy; Sam Ng | Zendy; Michael S. Noble | Zendy; Evan Paull | Zendy; Arvind Rao | Zendy; Sheila M. Reynolds | Zendy; Gordon Saksena | Zendy; Zack Sanborn | Zendy; Chris Sander | Zendy; Nikolaus Schultz | Zendy; Yasin Şenbabaoğlu | Zendy; Ronglai Shen | Zendy; Ilya Shmulevich | Zendy; Rileen Sinha | Zendy; S. Onur Sumer | Zendy; Yichao Sun | Zendy; Natalie Tasman | Zendy; Barry S. Taylor | Zendy; Doug Voet | Zendy; Nils Weinhold | Zendy; John N. Weinstein | Zendy; Da Yang | Zendy; Kosuke Yoshihara | Zendy; Siyuan Zheng | Zendy; Wei Zhang | Zendy; Lihua Zou | Zendy; Ty W. Abel | Zendy; Sara Sadeghi | Zendy; Mark L. Cohen | Zendy; Jenny Eschbacher | Zendy; Eyas M. Hattab | Zendy; Aditya Raghunathan | Zendy; Matthew Schniederjan | Zendy; Dina Aziz | Zendy; Gene H. Barnett | Zendy; Wendi Barrett | Zendy; Darell D. Bigner | Zendy; Lori Boice | Zendy; Cathy Brewer | Zendy; Chiara Calatozzolo | Zendy; Benito Campos | Zendy; Carlos Gilberto Carlotti | Zendy; Timothy A. Chan | Zendy; Lucia Cuppini | Zendy; Erin Curley | Zendy; Stefania Cuzzubbo | Zendy; Karen Devine | Zendy; Francesco DiMeco | Zendy; Rebecca Duell | Zendy; J. Bradley Elder | Zendy; Ashley Fehrenbach | Zendy; Gaetano Finocchiaro | Zendy; William E. Friedman | Zendy; Jordonna Fulop | Zendy; Johanna Gardner | Zendy; Beth Hermes | Zendy; Christel HeroldMende | Zendy; Christine Jungk | Zendy; Ady Kendler | Zendy; Norman L. Lehman | Zendy; Eric Lipp | Zendy; Ouida Liu | Zendy; Randy Mandt | Zendy; Mary McGraw | Zendy; Roger E. McLendon | Zendy; Christopher McPherson | Zendy; Luciano Neder | Zendy; Phuong L. Nguyen | Zendy; Ardene Noss | Zendy; R. Nunziata | Zendy; Quinn T. Ostrom | Zendy; Cheryl A. Palmer | Zendy; Alessandro Perin | Zendy; Bianca Pollo | Zendy; Potapov Aa | Zendy; Olga Potapova | Zendy; W. Kimryn Rathmell | Zendy; Д. Л. Ротин | Zendy; Lisa Scarpace | Zendy; Cathy Schilero | Zendy; Kelly Senecal | Zendy; Kristen Shimmel | Zendy; Vsevolod Shurkhay | Zendy; Suzanne Sifri | Zendy; Rosy Singh | Zendy; Andrew E. Sloan | Zendy; Kathy Smolenski | Zendy; Susan M. Staugaitis | Zendy; Ruth Steele | Zendy; Leigh B. Thorne | Zendy; Daniela Pretti da Cunha Tirapelli | Zendy; Andreas Unterberg | Zendy; Mahitha Vallurupalli | Zendy; Yun Wang | Zendy; Ronald E. Warnick | Zendy; Cecilia Williams | Zendy; Yingli Wolinsky | Zendy; Sue Bell | Zendy; Mara Rosenberg | Zendy; Chip Stewart | Zendy; Franklin W. Huang | Zendy; Jonna Grimsby | Zendy; Amie Radenbaugh | Zendy; Jianan Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

Author(s) -

Daniel J. Brat,

Roel G.W. Verhaak,

Kenneth D. Aldape,

W. K. Alfred Yung,

Sofie R. Salama,

Lee Cooper,

Esther Rheinbay,

C. Ryan Miller,

Mark Vitucci,

Olena Morozova,

A. Gordon Robertson,

Houtan Noushmehr,

Peter W. Laird,

Andrew D. Cherniack,

Rehan Akbani,

Jason T. Huse,

Giovanni Ciriello,

Laila Poisson,

Jill S. BarnholtzSloan,

Mitchel S. Berger,

Cameron Brennan,

Rivka R. Colen,

Howard Colman,

Adam E. Flanders,

Caterina Giannini,

Mia Grifford,

Antonio Iavarone,

Rajan Jain,

Isaac Joseph,

Jaegil Kim,

L. Sylvia,

Tom Mikkelsen,

Bradley A. Murray,

Brian Patrick O’Neill,

Lior Pachter,

D. Williams Parsons,

Carrie Sougnez,

Erik P. Sulman,

Scott R. VandenBerg,

Erwin G. Van Meir,

Andreas von Deimling,

Hailei Zhang,

Daniel Crain,

Kevin Lau,

David Mallery,

Scott Morris,

Joseph Paulauskis,

Robert Penny,

Troy Shelton,

Mark E. Sherman,

Peggy Yena,

Aaron Black,

Jay Bowen,

Katie Dicostanzo,

Julie M. GastierFoster,

Kristen Leraas,

Tara M. Lichtenberg,

Christopher R. Pierson,

Nilsa C. Ramirez,

Cynthia Taylor,

Stephanie Weaver,

Lisa Wise,

Erik Zmuda,

Tanja M. Davidsen,

John A. Demchok,

Greg Eley,

Martin L. Ferguson,

Carolyn M. Hutter,

Kenna Shaw,

Bradley A. Ozenberger,

Margi Sheth,

Heidi J. Sofia,

Roy Tarnuzzer,

Linghua Wang,

Liming Yang,

Jean C. Zenklusen,

Brenda Ayala,

Julien Baboud,

Sudha Chudamani,

Mark A. Jensen,

Jia Liu,

Todd Pihl,

Rohini Raman,

Yunhu Wan,

Ye Wu,

Adrian Ally,

J. Todd Auman,

Miruna Balasundaram,

Saianand Balu,

Stephen B. Baylin,

Rameen Beroukhim,

Arnoud Boot,

Reanne Bowlby,

Christopher A. Bristow,

Denise Brooks,

Yaron S.N. Butterfield,

Rebecca Carlsen,

Scott L. Carter,

Lynda Chin,

Andy Chu,

Eric Chuah,

Kristian Cibulskis,

Amanda Clarke,

Simon G. Coetzee,

Noreen Dhalla,

Timothy R. Fennell,

Sheila Fisher,

Stacey Gabriel,

Gad Getz,

Richard A. Gibbs,

Ranabir Guin,

Angela Hadjipanayis,

D. Neil Hayes,

Toshinori Hinoue,

Katherine A. Hoadley,

Robert A. Holt,

Alan P. Hoyle,

Joshua M. Stuart,

Steven J.M. Jones,

Corbin D. Jones,

Raju Kucherlapati,

Phillip H. Lai,

Eric S. Lander,

Semin Lee,

Lee Lichtenstein,

Yussanne Ma,

Dennis T. Maglinte,

Harshad S. Mahadeshwar,

Marco A. Marra,

Michael Mayo,

Shaowu Meng,

Matthew Meyerson,

Piotr A. Mieczkowski,

Richard A. Moore,

Lisle E. Mose,

Andrew J. Mungall,

Angeliki Pantazi,

Michael Parfenov,

Peter J. Park,

Joel S. Parker,

Charles M. Perou,

Alexei Protopopov,

Xiaojia Ren,

Jeffrey Roach,

Thaís S. Sabedot,

Jacqueline E. Schein,

Steven E. Schumacher,

Jonathan G. Seidman,

Sahil Seth,

Hui Shen,

Janae V. Simons,

Payal Sipahimalani,

Matthew G. Soloway,

Xingzhi Song,

Huandong Sun,

Barbara Tabak,

Angela Tam,

Donghui Tan,

Jiabin Tang,

Nina Thiessen,

Timothy J. Triche,

David Van Den Berg,

Umadevi Veluvolu,

Stephen C. Waring,

Daniel J. Weisenberger,

Matthew D. Wilkerson,

Tina Wong,

Junyuan Wu,

Xi Liu,

Andrew Wei Xu,

Lixing Yang,

Travis Zack,

Jianhua Zhang,

Bülent Arman Aksoy,

Harindra Arachchi,

Chris Benz,

Brady Bernard,

Daniel E. Carlin,

Juok Cho,

Daniel DiCara,

Scott Frazer,

Gregory N. Fuller,

Jian Jiong Gao,

Nils Gehlenborg,

David Haussler,

David I. Heiman,

Lisa Iype,

Anders J. Skanderup,

Zhenlin Ju,

Sol Katzman,

Hoon Kim,

Theo Knijnenburg,

Richard Kreisberg,

Michael S. Lawrence,

William Lee,

Kalle Lein,

Pei Lin,

Shiyun Ling,

Wenbin Liu,

Yingchun Liu,

Yuexin Liu,

Yiling Lu,

Gordon B. Mills,

Sam Ng,

Michael S. Noble,

Evan Paull,

Arvind Rao,

Sheila M. Reynolds,

Gordon Saksena,

Zack Sanborn,

Chris Sander,

Nikolaus Schultz,

Yasin Şenbabaoğlu,

Ronglai Shen,

Ilya Shmulevich,

Rileen Sinha,

S. Onur Sumer,

Yichao Sun,

Natalie Tasman,

Barry S. Taylor,

Doug Voet,

Nils Weinhold,

John N. Weinstein,

Da Yang,

Kosuke Yoshihara,

Siyuan Zheng,

Wei Zhang,

Lihua Zou,

Ty W. Abel,

Sara Sadeghi,

Mark L. Cohen,

Jenny Eschbacher,

Eyas M. Hattab,

Aditya Raghunathan,

Matthew Schniederjan,

Dina Aziz,

Gene H. Barnett,

Wendi Barrett,

Darell D. Bigner,

Lori Boice,

Cathy Brewer,

Chiara Calatozzolo,

Benito Campos,

Carlos Gilberto Carlotti,

Timothy A. Chan,

Lucia Cuppini,

Erin Curley,

Stefania Cuzzubbo,

Karen Devine,

Francesco DiMeco,

Rebecca Duell,

J. Bradley Elder,

Ashley Fehrenbach,

Gaetano Finocchiaro,

William E. Friedman,

Jordonna Fulop,

Johanna Gardner,

Beth Hermes,

Christel HeroldMende,

Christine Jungk,

Ady Kendler,

Norman L. Lehman,

Eric Lipp,

Ouida Liu,

Randy Mandt,

Mary McGraw,

Roger E. McLendon,

Christopher McPherson,

Luciano Neder,

Phuong L. Nguyen,

Ardene Noss,

R. Nunziata,

Quinn T. Ostrom,

Cheryl A. Palmer,

Alessandro Perin,

Bianca Pollo,

Potapov Aa,

Olga Potapova,

W. Kimryn Rathmell,

Д. Л. Ротин,

Lisa Scarpace,

Cathy Schilero,

Kelly Senecal,

Kristen Shimmel,

Vsevolod Shurkhay,

Suzanne Sifri,

Rosy Singh,

Andrew E. Sloan,

Kathy Smolenski,

Susan M. Staugaitis,

Ruth Steele,

Leigh B. Thorne,

Daniela Pretti da Cunha Tirapelli,

Andreas Unterberg,

Mahitha Vallurupalli,

Yun Wang,

Ronald E. Warnick,

Cecilia Williams,

Yingli Wolinsky,

Sue Bell,

Mara Rosenberg,

Chip Stewart,

Franklin W. Huang,

Jonna Grimsby,

Amie Radenbaugh,

Jianan Zhang

Publication year - 2015

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1402121

Subject(s) - atrx , glioma , medicine , dna methylation , exome , cancer research , exome sequencing , mutation , oncology , biology , genetics , gene , gene expression

Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly progress to glioblastoma. The uncertainty is compounded by interobserver variability in histologic diagnosis. Mutations in IDH, TP53, and ATRX and codeletion of chromosome arms 1p and 19q (1p/19q codeletion) have been implicated as clinically relevant markers of lower-grade gliomas.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research