Controlled Trial of Transfusions for Silent Cerebral Infarcts in Sickle Cell Anemia
Author(s) -
Michael R. DeBaun,
Mae O. Gordon,
Robert C. McKinstry,
Michael J. Noetzel,
Desirée A. White,
Sharada A. Sarnaik,
Emily Riehm Meier,
Thomas H. Howard,
Suvankar Majumdar,
Baba Inusa,
Paul Telfer,
Melanie KirbyAllen,
Timothy L. McCavit,
Annie Kamdem,
Gladstone Airewele,
Gerald M. Woods,
Brian Berman,
Julie A. Panepinto,
Beng Fuh,
Janet L. Kwiatkowski,
Allison A. King,
Jason Fixler,
Melissa Rhodes,
Alexis A. Thompson,
Mark E. Heiny,
Rupa ReddingLallinger,
Fenella J. Kirkham,
Natalia Dixon,
Corina Gonzalez,
Karen Kalinyak,
Charles T. Quinn,
John J. Strouse,
J. Philip Miller,
Harold P. Lehmann,
Michael A. Kraut,
William S. Ball,
Deborah Hirtz,
James F. Casella
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1401731
Subject(s) - medicine , sickle cell anemia , anemia , pediatrics , disease
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct). We tested the hypothesis that the incidence of the recurrence of an infarct would be lower among children who underwent regular blood-transfusion therapy than among those who received standard care.
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