Evidence for Camel-to-Human Transmission of MERS Coronavirus | Zendy

Esam I. Azhar | Zendy; Sherif A. ElKafrawy | Zendy; Suha A. Farraj | Zendy; Ahmed M. Hassan | Zendy; Muneera S. Al-Saeed | Zendy; Anwar M. Hashem | Zendy; Tariq A. Madani | Zendy

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Evidence for Camel-to-Human Transmission of MERS Coronavirus

Author(s) -

Esam I. Azhar,

Sherif A. ElKafrawy,

Suha A. Farraj,

Ahmed M. Hassan,

Muneera S. Al-Saeed,

Anwar M. Hashem,

Tariq A. Madani

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1401505

Subject(s) - middle east respiratory syndrome coronavirus , virology , serology , transmission (telecommunications) , isolation (microbiology) , rhinorrhea , covid-19 , biology , coronavirus , medicine , antibody , immunology , infectious disease (medical specialty) , microbiology and biotechnology , pathology , disease , electrical engineering , engineering

We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic data indicated that MERS-CoV was circulating in the camels but not in the patient before the human infection occurred. These data suggest that this fatal case of human MERS-CoV infection was transmitted through close contact with an infected camel.

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