Breast-Cancer Risk in Families with Mutations in PALB2 | Zendy

Antonis C. Antoniou | Zendy; Silvia Casadei | Zendy; Tuomas Heikkinen | Zendy; Daniel Barrowdale | Zendy; Katri Pylkäs | Zendy; Jonathan Roberts | Zendy; Andrew Lee | Zendy; Deepak Subramanian | Zendy; Kim De Leeneer | Zendy; Florentia Fostira | Zendy; Eva Tomiak | Zendy; Susan L. Neuhausen | Zendy; Zhi L. Teo | Zendy; Sofia Khan | Zendy; Kristiina Aittomäki | Zendy; Jukka S. Moilanen | Zendy; Clare Turnbull | Zendy; Sheila Seal | Zendy; Graham J. Mann | Zendy; Anne Kallioniemi | Zendy; Geoffrey J. Lindeman | Zendy; Saundra S. Buys | Zendy; Irene L. Andrulis | Zendy; Paolo Radice | Zendy; Carlo Tondini | Zendy; Siranoush Manoukian | Zendy; Amanda E. Toland | Zendy; Penelope Miron | Zendy; Jeffrey N. Weitzel | Zendy; Susan M. Domchek | Zendy; Bruce Poppe | Zendy; Kathleen Claes | Zendy; Drakoulis Yannoukakos | Zendy; Patrick Concan | Zendy; Jonine L. Bernstein | Zendy; Paul A. James | Zendy; Douglas F. Easton | Zendy; David E. Goldgar | Zendy; John L. Hopper | Zendy; Nazneen Rahman | Zendy; Paolo Peterlongo | Zendy; Heli Nevanlinna | Zendy; MaryClaire King | Zendy; Fergus J. Couch | Zendy; Melissa C. Southey | Zendy; Robert Winqvist | Zendy; William D. Foulkes | Zendy; Marc Tischkowitz | Zendy

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Breast-Cancer Risk in Families with Mutations in PALB2

Author(s) -

Antonis C. Antoniou,

Silvia Casadei,

Tuomas Heikkinen,

Daniel Barrowdale,

Katri Pylkäs,

Jonathan Roberts,

Andrew Lee,

Deepak Subramanian,

Kim De Leeneer,

Florentia Fostira,

Eva Tomiak,

Susan L. Neuhausen,

Zhi L. Teo,

Sofia Khan,

Kristiina Aittomäki,

Jukka S. Moilanen,

Clare Turnbull,

Sheila Seal,

Graham J. Mann,

Anne Kallioniemi,

Geoffrey J. Lindeman,

Saundra S. Buys,

Irene L. Andrulis,

Paolo Radice,

Carlo Tondini,

Siranoush Manoukian,

Amanda E. Toland,

Penelope Miron,

Jeffrey N. Weitzel,

Susan M. Domchek,

Bruce Poppe,

Kathleen Claes,

Drakoulis Yannoukakos,

Patrick Concan,

Jonine L. Bernstein,

Paul A. James,

Douglas F. Easton,

David E. Goldgar,

John L. Hopper,

Nazneen Rahman,

Paolo Peterlongo,

Heli Nevanlinna,

MaryClaire King,

Fergus J. Couch,

Melissa C. Southey,

Robert Winqvist,

William D. Foulkes,

Marc Tischkowitz

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1400382

Subject(s) - breast cancer , palb2 , medicine , oncology , germline mutation , cancer , population , family history , risk factor , mutation , genetics , biology , environmental health , gene

Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown.

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