Open AccessBrain Swelling and Death in Children with Cerebral Malaria
Author(s) -
Karl B. Seydel,
Samuel Kampondeni,
Clarissa Valim,
Michael J. Potchen,
Danny A. Milner,
Francis Muwalo,
Gretchen L. Birbeck,
William G. Bradley,
Lindsay Fox,
Simon J. Glover,
Colleen Hammond,
Robert S. Heyderman,
Cowles Chilingulo,
Malcolm E. Molyneux,
Terrie E. Taylor
Publication year - 2015
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1400116
Subject(s) - cerebral malaria , medicine , intracranial pressure , case fatality rate , magnetic resonance imaging , coma (optics) , pediatrics , cerebral edema , brain swelling , pathological , malaria , pathology , surgery , radiology , epidemiology , plasmodium falciparum , physics , optics
Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.
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