Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes | Zendy

Jessica S. Albert | Zendy; Laura M. YergesArmstrong | Zendy; Richard B. Horenstein | Zendy; Toni I. Pollin | Zendy; Urmila Sreenivasan | Zendy; Sumbul Chai | Zendy; William S. Blaner | Zendy; Søren Snitker | Zendy; Jeffrey R. O’Connell | Zendy; Da-Wei Gong | Zendy; Richard J. Breyer | Zendy; Alice S. Ryan | Zendy; John C. McLenithan | Zendy; Alan R. Shuldiner | Zendy; Carole Sztalryd | Zendy; Coleen Damcott | Zendy

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Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

Author(s) -

Jessica S. Albert,

Laura M. YergesArmstrong,

Richard B. Horenstein,

Toni I. Pollin,

Urmila Sreenivasan,

Sumbul Chai,

William S. Blaner,

Søren Snitker,

Jeffrey R. O’Connell,

Da-Wei Gong,

Richard J. Breyer,

Alice S. Ryan,

John C. McLenithan,

Alan R. Shuldiner,

Carole Sztalryd,

Coleen Damcott

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1315496

Subject(s) - endocrinology , medicine , lipolysis , insulin resistance , adipose tissue , adipose triglyceride lipase , biology , glucose homeostasis , hormone sensitive lipase , type 2 diabetes , lipid metabolism , insulin , diabetes mellitus

Lipolysis regulates energy homeostasis through the hydrolysis of intracellular triglycerides and the release of fatty acids for use as energy substrates or lipid mediators in cellular processes. Genes encoding proteins that regulate energy homeostasis through lipolysis are thus likely to play an important role in determining susceptibility to metabolic disorders.

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