A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings | Zendy

Christina D. Orrú | Zendy; Matilde Bongianni | Zendy; Giovanni Tonoli | Zendy; Sérgio Ferrari | Zendy; Andrew G. Hughson | Zendy; Bradley R. Groveman | Zendy; Michele Fiorini | Zendy; Maurizio Pocchiari | Zendy; Salvatore Monaco | Zendy; Byron Caughey | Zendy; Gianluigi Zanusso | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

Author(s) -

Christina D. Orrú,

Matilde Bongianni,

Giovanni Tonoli,

Sérgio Ferrari,

Andrew G. Hughson,

Bradley R. Groveman,

Michele Fiorini,

Maurizio Pocchiari,

Salvatore Monaco,

Byron Caughey,

Gianluigi Zanusso

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1315200

Subject(s) - medicine , cerebrospinal fluid , pathology , creutzfeldt jakob syndrome , disease , virology , prion protein

Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge. A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of real-time quaking-induced conversion (RT-QuIC) testing of cerebrospinal fluid has a sensitivity of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease. We have assessed the accuracy of RT-QuIC analysis of nasal brushings from olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research