Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis | Zendy

David R. Boulware | Zendy; David B. Meya | Zendy; Conrad Muzoora | Zendy; Melissa A. Rolfes | Zendy; Katherine Huppler Hullsiek | Zendy; Abdu Musubire | Zendy; Kabanda Taseera | Zendy; Henry W. Nabeta | Zendy; Charlotte Schutz | Zendy; Darlisha A Williams | Zendy; Radha Rajasingham | Zendy; Joshua Rhein | Zendy; Friedrich Thienemann | Zendy; Melanie Lo | Zendy; Kirsten Nielsen | Zendy; Tracy L. Bergemann | Zendy; Andrew Kambugu | Zendy; Yukari C. Manabe | Zendy; Edward N. Janoff | Zendy; Paul R. Bohjanen | Zendy; Graeme Meintjes | Zendy

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Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis

Author(s) -

David R. Boulware,

David B. Meya,

Conrad Muzoora,

Melissa A. Rolfes,

Katherine Huppler Hullsiek,

Abdu Musubire,

Kabanda Taseera,

Henry W. Nabeta,

Charlotte Schutz,

Darlisha A Williams,

Radha Rajasingham,

Joshua Rhein,

Friedrich Thienemann,

Melanie Lo,

Kirsten Nielsen,

Tracy L. Bergemann,

Andrew Kambugu,

Yukari C. Manabe,

Edward N. Janoff,

Paul R. Bohjanen,

Graeme Meintjes

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1312884

Subject(s) - medicine , hazard ratio , cryptococcosis , amphotericin b , meningitis , fluconazole , incidence (geometry) , cryptococcal meningitis , mortality rate , confidence interval , antiretroviral therapy , pediatrics , surgery , human immunodeficiency virus (hiv) , viral load , immunology , antifungal , viral disease , dermatology , physics , optics

Cryptococcal meningitis accounts for 20 to 25% of acquired immunodeficiency syndrome-related deaths in Africa. Antiretroviral therapy (ART) is essential for survival; however, the question of when ART should be initiated after diagnosis of cryptococcal meningitis remains unanswered.

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