Antidepressant Use in Pregnancy and the Risk of Cardiac Defects | Zendy

Krista F. Huybrechts | Zendy; Kristin Palmsten | Zendy; Jerry Avorn | Zendy; Lee S. Cohen | Zendy; Lewis B. Holmes | Zendy; Jessica M. Franklin | Zendy; Helen Mogun | Zendy; Raisa Levin | Zendy; Mary K. Kowal | Zendy; Soko Setoguchi | Zendy; Sonia Hernández–Dı́az | Zendy

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Antidepressant Use in Pregnancy and the Risk of Cardiac Defects

Author(s) -

Krista F. Huybrechts,

Kristin Palmsten,

Jerry Avorn,

Lee S. Cohen,

Lewis B. Holmes,

Jessica M. Franklin,

Helen Mogun,

Raisa Levin,

Mary K. Kowal,

Soko Setoguchi,

Sonia Hernández–Dı́az

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1312828

Subject(s) - medicine , pregnancy , sertraline , relative risk , cohort , depression (economics) , antidepressant , cohort study , confounding , obstetrics , paroxetine , confidence interval , pediatrics , serotonin reuptake inhibitor , psychiatry , anxiety , genetics , biology , macroeconomics , economics

Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other antidepressants during pregnancy is associated with an increased risk of congenital cardiac defects is uncertain. In particular, there are concerns about a possible association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects.

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