A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon | Zendy

Talitha I. Verhoef | Zendy; Georgia Ragia | Zendy; Anthonius de Boer | Zendy; Rita Barallon | Zendy; Genovefa Kolovou | Zendy; Vana Kolovou | Zendy; Stavros Konstantinides | Zendy; Saskia le Cessie | Zendy; Efstratios Maltezos | Zendy; F.J.M. van der Meer | Zendy; Ken Redekop | Zendy; M.G.H. Remkes | Zendy; Frits R. Rosendaal | Zendy; Rianne MF van Schie | Zendy; Anna Tavridou | Zendy; Dimitrios Tziakas | Zendy; Mia Wadelius | Zendy; Vangelis G. Manolopoulos | Zendy; Anke H. Maitlandvan der Zee | Zendy

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A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon

Author(s) -

Talitha I. Verhoef,

Georgia Ragia,

Anthonius de Boer,

Rita Barallon,

Genovefa Kolovou,

Vana Kolovou,

Stavros Konstantinides,

Saskia le Cessie,

Efstratios Maltezos,

F.J.M. van der Meer,

Ken Redekop,

M.G.H. Remkes,

Frits R. Rosendaal,

Rianne MF van Schie,

Anna Tavridou,

Dimitrios Tziakas,

Mia Wadelius,

Vangelis G. Manolopoulos,

Anke H. Maitlandvan der Zee

Publication year - 2013

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1311388

Subject(s) - phenprocoumon , acenocoumarol , dosing , medicine , observational study , randomized controlled trial , vkorc1 , anesthesia , cyp2c9 , intensive care medicine , pharmacology , warfarin , atrial fibrillation , cytochrome p450 , metabolism

Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy.

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