A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus | Zendy

Maria Grazia Revello | Zendy; Tiziana Lazzarotto | Zendy; Brunella Guerra | Zendy; Arsenio Spinillo | Zendy; E. Ferrazzi | Zendy; Alessandra Kustermann | Zendy; Secondo Guaschino | Zendy; Patrizia Vergani | Zendy; Tullia Todros | Zendy; T. Frusca | Zendy; Alessia Arossa | Zendy; Milena Furione | Zendy; Vanina Rogi | Zendy; Nicola Rizzo | Zendy; Liliana Gabrielli | Zendy; Catherine Klersy | Zendy; Giuseppe Gerna | Zendy

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A Randomized Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus

Author(s) -

Maria Grazia Revello,

Tiziana Lazzarotto,

Brunella Guerra,

Arsenio Spinillo,

E. Ferrazzi,

Alessandra Kustermann,

Secondo Guaschino,

Patrizia Vergani,

Tullia Todros,

T. Frusca,

Alessia Arossa,

Milena Furione,

Vanina Rogi,

Nicola Rizzo,

Liliana Gabrielli,

Catherine Klersy,

Giuseppe Gerna

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1310214

Subject(s) - medicine , cytomegalovirus , cytomegalovirus infections , globulin , randomized controlled trial , human cytomegalovirus , immunology , pregnancy , virology , betaherpesvirinae , pediatrics , viral disease , herpesviridae , virus , genetics , biology

Congenital infection with human cytomegalovirus (CMV) is a major cause of morbidity and mortality. In an uncontrolled study published in 2005, administration of CMV-specific hyperimmune globulin to pregnant women with primary CMV infection significantly reduced the rate of intrauterine transmission, from 40% to 16%.

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