A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma | Zendy

Mark R. Gilbert | Zendy; James J. Dignam | Zendy; Terri S. Armstrong | Zendy; Jeffrey S. Wefel | Zendy; Deborah T. Blumenthal | Zendy; Michael A. Vogelbaum | Zendy; Howard Colman | Zendy; Arnab Chakravarti | Zendy; Stephanie L. Pugh | Zendy; Minhee Won | Zendy; Robert Jeraj | Zendy; Paul D. Brown | Zendy; Kurt A. Jaeckle | Zendy; David Schiff | Zendy; Volker W. Stieber | Zendy; David Brachman | Zendy; Maria WernerWasik | Zendy; Ivo W. TremontLukats | Zendy; Erik P. Sulman | Zendy; Kenneth Aldape | Zendy; Walter J. Curran | Zendy; Minesh P. Mehta | Zendy

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A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Author(s) -

Mark R. Gilbert,

James J. Dignam,

Terri S. Armstrong,

Jeffrey S. Wefel,

Deborah T. Blumenthal,

Michael A. Vogelbaum,

Howard Colman,

Arnab Chakravarti,

Stephanie L. Pugh,

Minhee Won,

Robert Jeraj,

Paul D. Brown,

Kurt A. Jaeckle,

David Schiff,

Volker W. Stieber,

David Brachman,

Maria WernerWasik,

Ivo W. TremontLukats,

Erik P. Sulman,

Kenneth Aldape,

Walter J. Curran,

Minesh P. Mehta

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1308573

Subject(s) - bevacizumab , temozolomide , medicine , glioblastoma , oncology , standard of care , radiation therapy , vascular endothelial growth factor , randomized controlled trial , chemotherapy , vegf receptors , cancer research

Concurrent treatment with temozolomide and radiotherapy followed by maintenance temozolomide is the standard of care for patients with newly diagnosed glioblastoma. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor A, is currently approved for recurrent glioblastoma. Whether the addition of bevacizumab would improve survival among patients with newly diagnosed glioblastoma is not known.

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