Patches of Disorganization in the Neocortex of Children with Autism | Zendy

Rich Stoner | Zendy; Maggie Chow | Zendy; Maureen P. Boyle | Zendy; Susan M. Sunkin | Zendy; Peter R. Mouton | Zendy; Subhojit Roy | Zendy; Anthony WynshawBoris | Zendy; Sophia A. Colamarino | Zendy; Ed S. Lein | Zendy; Eric Courchesne | Zendy

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Patches of Disorganization in the Neocortex of Children with Autism

Author(s) -

Rich Stoner,

Maggie Chow,

Maureen P. Boyle,

Susan M. Sunkin,

Peter R. Mouton,

Subhojit Roy,

Anthony WynshawBoris,

Sophia A. Colamarino,

Ed S. Lein,

Eric Courchesne

Publication year - 2014

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1307491

Subject(s) - neocortex , autism , prefrontal cortex , neuroscience , pathological , medicine , cortex (anatomy) , brain development , concomitant , psychology , psychiatry , cognition

Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development.

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