Daclatasvir plus Sofosbuvir for Previously Treated or Untreated Chronic HCV Infection
Author(s) -
Mark Sulkowski,
David Gardiner,
M. RodríguezTorres,
K. Rajender Reddy,
Tarek Hassanein,
Ira M. Jacobson,
Eric Lawitz,
Anna S. Lok,
Federico Hinestrosa,
Paul J. Thuluvath,
Howard Schwartz,
David R. Nelson,
Gregory T. Everson,
Timothy Eley,
Megan WindRotolo,
Shu-Pang Huang,
Min Gao,
Dennis Hernandez,
Fiona McPhee,
Diane L. Sherman,
R. Hindes,
William T. Symonds,
C Pasquinelli,
Dennis M. Grasela
Publication year - 2014
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1306218
Subject(s) - daclatasvir , sofosbuvir , ns5a , medicine , ns5b , virology , hepatitis c virus , genotype , chronic hepatitis , hepacivirus , virus , ribavirin , gene , biology , genetics
All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated daclatasvir (an HCV NS5A replication complex inhibitor) plus sofosbuvir (a nucleotide analogue HCV NS5B polymerase inhibitor) in patients infected with HCV genotype 1, 2, or 3.
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