Reduced Cortisol Metabolism during Critical Illness | Zendy

Eva Boonen | Zendy; Hilke Vervenne | Zendy; Philippe Meersseman | Zendy; Ruth Andrew | Zendy; Leen Mortier | Zendy; Peter Declercq | Zendy; Yoo-Mee Vanwijngaerden | Zendy; Isabel Spriet | Zendy; Pieter Wouters | Zendy; Sarah Vander Perre | Zendy; Lies Langouche | Zendy; Ilse Vanhorebeek | Zendy; Brian R. Walker | Zendy; Greet Van den Berghe | Zendy

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Reduced Cortisol Metabolism during Critical Illness

Author(s) -

Eva Boonen,

Hilke Vervenne,

Philippe Meersseman,

Ruth Andrew,

Leen Mortier,

Peter Declercq,

Yoo-Mee Vanwijngaerden,

Isabel Spriet,

Pieter Wouters,

Sarah Vander Perre,

Lies Langouche,

Ilse Vanhorebeek,

Brian R. Walker,

Greet Van den Berghe

Publication year - 2013

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1214969

Subject(s) - endocrinology , medicine , hypercortisolemia , hydrocortisone , hormone , glucocorticoid , urinary system , metabolism , adrenal insufficiency , stimulation

Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism.

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