Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma
Author(s) -
Minal Çalışkan,
Yury A. Bochkov,
Eskil KreinerMøller,
Klaus Bønnelykke,
Michelle M. Stein,
Gaixin Du,
Hans Bisgaard,
Daniel J. Jackson,
James E. Gern,
Robert F. Lemanske,
Dan L. Nicolae,
Carole Ober
Publication year - 2013
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1211592
Subject(s) - rhinovirus , asthma , medicine , locus (genetics) , genotype , immunology , respiratory system , peripheral blood mononuclear cell , virus , gene , genetics , biology , in vitro
Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing illnesses are associated with the development of asthma. Our aim was to determine the effects of these two factors on the risk of asthma in the Childhood Origins of Asthma (COAST) and the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohorts.
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