Variant ofTREM2Associated with the Risk of Alzheimer's Disease | Zendy

Thorlákur Jónsson | Zendy; Hreinn Stefánsson | Zendy; Stacy Steinberg | Zendy; Ingileif Jónsdóttir | Zendy; Pálmi V. Jónsson | Zendy; Jón Snædal | Zendy; Sigurbjörn Björnsson | Zendy; Johanna Huttenlocher | Zendy; Allan I. Levey | Zendy; James J. Lah | Zendy; Dan Rujescu | Zendy; Harald Hampel | Zendy; Ina Giegling | Zendy; Ole A. Andreassen | Zendy; Knut Engedal | Zendy; Ingun Ulstein | Zendy; Srdjan Djurovic | Zendy; Carla A. IbrahimVerbaas | Zendy; Albert Hofman | Zendy; M. Arfan Ikram | Zendy; Cornelia M. van Duijn | Zendy; Unnur Þorsteinsdóttir | Zendy; Augustine Kong | Zendy; Kári Stéfansson | Zendy

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Variant ofTREM2Associated with the Risk of Alzheimer's Disease

Author(s) -

Thorlákur Jónsson,

Hreinn Stefánsson,

Stacy Steinberg,

Ingileif Jónsdóttir,

Pálmi V. Jónsson,

Jón Snædal,

Sigurbjörn Björnsson,

Johanna Huttenlocher,

Allan I. Levey,

James J. Lah,

Dan Rujescu,

Harald Hampel,

Ina Giegling,

Ole A. Andreassen,

Knut Engedal,

Ingun Ulstein,

Srdjan Djurovic,

Carla A. IbrahimVerbaas,

Albert Hofman,

M. Arfan Ikram,

Cornelia M. van Duijn,

Unnur Þorsteinsdóttir,

Augustine Kong,

Kári Stéfansson

Publication year - 2012

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1211103

Subject(s) - trem2 , odds ratio , alzheimer's disease , medicine , disease , allele , case control study , missense mutation , apolipoprotein e , population , confidence interval , genetics , mutation , biology , gene , receptor , myeloid cells , environmental health

Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found.

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