Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer | Zendy

Alan L. Ho | Zendy; Ravinder K. Grewal | Zendy; Rebecca Lebœuf | Zendy; Eric J. Sherman | Zendy; David G. Pfister | Zendy; Désirèe Deandreis | Zendy; Keith S. Pentlow | Zendy; Pat Zanzonico | Zendy; Sofia Haque | Zendy; Somali Gavane | Zendy; Ronald Ghossein | Zendy; Julio C. RicarteFilho | Zendy; José Miguel Domínguez | Zendy; Ronglai Shen | Zendy; R. Michael Tuttle | Zendy; Steven M. Larson | Zendy; James A. Fagin | Zendy

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Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer

Author(s) -

Alan L. Ho,

Ravinder K. Grewal,

Rebecca Lebœuf,

Eric J. Sherman,

David G. Pfister,

Désirèe Deandreis,

Keith S. Pentlow,

Pat Zanzonico,

Sofia Haque,

Somali Gavane,

Ronald Ghossein,

Julio C. RicarteFilho,

José Miguel Domínguez,

Ronglai Shen,

R. Michael Tuttle,

Steven M. Larson,

James A. Fagin

Publication year - 2013

Publication title -

new england journal of medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1209288

Subject(s) - medicine , sodium iodide symporter , selumetinib , thyroid cancer , iodine , thyroid , symporter , cancer research , protein kinase a , cancer , mapk/erk pathway , sodium iodide , endocrinology , oncology , radioactive iodine , kinase , transporter , biochemistry , materials science , colorectal cancer , metallurgy , kras , gene , physics , nuclear physics , chemistry

Metastatic thyroid cancers that are refractory to radioiodine (iodine-131) are associated with a poor prognosis. In mouse models of thyroid cancer, selective mitogen-activated protein kinase (MAPK) pathway antagonists increase the expression of the sodium-iodide symporter and uptake of iodine. Their effects in humans are not known.

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