Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth
Author(s) -
Uma M. Reddy,
Grier P. Page,
George R. Saade,
Robert M. Silver,
Vanessa Thorsten,
Corette B. Parker,
Halit Pınar,
Marian Willinger,
Barbara J. Stoll,
Josefine HeimHall,
Michael W. Varner,
Robert L. Goldenberg,
Radek Bukowski,
Ronald J. Wapner,
Carolyn DrewsBotsch,
Barbara O’Brien,
Donald J. Dudley,
Brynn Levy
Publication year - 2012
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1201569
Subject(s) - karyotype , microarray , microarray analysis techniques , genetic testing , genetics , biology , copy number variation , chromosome , computational biology , gene , genome , gene expression
Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions and duplications called copy-number variants.
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