Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia | Zendy

Matthew J. Olnes | Zendy; Phillip Scheinberg | Zendy; Katherine R. Calvo | Zendy; Ronan Desmond | Zendy; Yong Tang | Zendy; Bogdan Dumitriu | Zendy; Ankur R. Parikh | Zendy; Susan Soto | Zendy; Angélique Biancotto | Zendy; Xingmin Feng | Zendy; Jay N. Lozier | Zendy; Colin O. Wu | Zendy; Neal S. Young | Zendy; Cynthia E. Dunbar | Zendy

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Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia

Author(s) -

Matthew J. Olnes,

Phillip Scheinberg,

Katherine R. Calvo,

Ronan Desmond,

Yong Tang,

Bogdan Dumitriu,

Ankur R. Parikh,

Susan Soto,

Angélique Biancotto,

Xingmin Feng,

Jay N. Lozier,

Colin O. Wu,

Neal S. Young,

Cynthia E. Dunbar

Publication year - 2012

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1200931

Subject(s) - medicine , eltrombopag , pancytopenia , aplastic anemia , gastroenterology , thrombopoietin , cytopenia , bone marrow , immunosuppression , anemia , myelodysplastic syndromes , immunology , haematopoiesis , platelet , stem cell , immune thrombocytopenia , genetics , biology

Severe aplastic anemia, which is characterized by immune-mediated bone marrow hypoplasia and pancytopenia, can be treated effectively with immunosuppressive therapy or allogeneic transplantation. One third of patients have disease that is refractory to immunosuppression, with persistent, severe cytopenia and a profound deficit in hematopoietic stem cells and progenitor cells. Thrombopoietin may increase the number of hematopoietic stem cells and progenitor cells.

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