Treatment of Older Patients with Mantle-Cell Lymphoma | Zendy

Hanneke C. KluinNelemans | Zendy; Eva Hoster | Zendy; Olivier Hermine | Zendy; Jan Walewski | Zendy; Marek Trněný | Zendy; Carsten Geisler | Zendy; Stephan Stilgenbauer | Zendy; Catherine Thiéblemont | Zendy; Ursula VehlingKaiser | Zendy; Jeanette K. Doorduijn | Zendy; Bertrand Coiffier | Zendy; Roswitha Forstpointner | Zendy; Hervé Tilly | Zendy; Lothar Kanz | Zendy; Pierre Feugier | Zendy; Michał Szymczyk | Zendy; Michael Hallek | Zendy; Stephan Kremers | Zendy; G. Lepeu | Zendy; Laurence Sanhès | Zendy; Josée M. Zijlstra | Zendy; Réda Bouabdallah | Zendy; Pieternella J. Lugtenburg | Zendy; Margaret Macro | Zendy; Michael Pfreundschuh | Zendy; Vít Procházka | Zendy; Francesco Di Raimondo | Zendy; Vincent Ribrag | Zendy; M. Uppenkamp | Zendy; Marc André | Zendy; W. Klapper | Zendy; W. Hiddemann | Zendy; Michael Unterhalt | Zendy; Martin Dreyling | Zendy

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Treatment of Older Patients with Mantle-Cell Lymphoma

Author(s) -

Hanneke C. KluinNelemans,

Eva Hoster,

Olivier Hermine,

Jan Walewski,

Marek Trněný,

Carsten Geisler,

Stephan Stilgenbauer,

Catherine Thiéblemont,

Ursula VehlingKaiser,

Jeanette K. Doorduijn,

Bertrand Coiffier,

Roswitha Forstpointner,

Hervé Tilly,

Lothar Kanz,

Pierre Feugier,

Michał Szymczyk,

Michael Hallek,

Stephan Kremers,

G. Lepeu,

Laurence Sanhès,

Josée M. Zijlstra,

Réda Bouabdallah,

Pieternella J. Lugtenburg,

Margaret Macro,

Michael Pfreundschuh,

Vít Procházka,

Francesco Di Raimondo,

Vincent Ribrag,

M. Uppenkamp,

Marc André,

W. Klapper,

W. Hiddemann,

Michael Unterhalt,

Martin Dreyling

Publication year - 2012

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1200920

Subject(s) - medicine , rituximab , vincristine , mantle cell lymphoma , chemoimmunotherapy , cyclophosphamide , fludarabine , chop , gastroenterology , prednisone , international prognostic index , regimen , surgery , maintenance therapy , lymphoma , chemotherapy

The long-term prognosis for older patients with mantle-cell lymphoma is poor. Chemoimmunotherapy results in low rates of complete remission, and most patients have a relapse. We investigated whether a fludarabine-containing induction regimen improved the complete-remission rate and whether maintenance therapy with rituximab prolonged remission.

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