Differentiation of Reinfection from Relapse in Recurrent Lyme Disease
Author(s) -
Robert B. Nadelman,
Klára Hanincová,
Priyanka Mukherjee,
Dionysios Liveris,
John Nowakowski,
Donna McKenna,
Dustin Brisson,
Denise R. Cooper,
Susan Bittker,
Guy Madison,
Diane Holmgren,
Ira Schwartz,
Gary P. Wormser
Publication year - 2012
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1114362
Subject(s) - erythema migrans , lyme disease , borrelia burgdorferi , medicine , dermatology , erythema chronicum migrans , disease , erythema , immunology , borrelia , lyme borreliosis , antibody
Erythema migrans is the most common manifestation of Lyme disease. Recurrences are not uncommon, and although they are usually attributed to reinfection rather than relapse of the original infection, this remains somewhat controversial. We used molecular typing of Borrelia burgdorferi isolates obtained from patients with culture-confirmed episodes of erythema migrans to distinguish between relapse and reinfection.
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