Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing | Zendy

Marco Gerlinger | Zendy; Andrew J. Rowan | Zendy; Stuart Horswell | Zendy; James Larkin | Zendy; David Endesfelder | Zendy; Eva Grönroos | Zendy; Pierre Martinez | Zendy; Nicholas Matthews | Zendy; Grant D. Stewart | Zendy; Patrick Tarpey | Zendy; Ignacio Varela | Zendy; Benjamin Phillimore | Zendy; Sharmin Begum | Zendy; Neil Q. McDonald | Zendy; Adam Butler | Zendy; David Jones | Zendy; Keiran Raine | Zendy; Calli Latimer | Zendy; Cláudio R. Santos | Zendy; Mahrokh Nohadani | Zendy; Aron C. Eklund | Zendy; Bradley SpencerDene | Zendy; Graham Clark | Zendy; Lisa Pickering | Zendy; Gordon Stamp | Zendy; Martin Gore | Zendy; Zoltán Szállási | Zendy; Julian Downward | Zendy; P. Andrew Futreal | Zendy; Charles Swanton | Zendy

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Author(s) -

Marco Gerlinger,

Andrew J. Rowan,

Stuart Horswell,

James Larkin,

David Endesfelder,

Eva Grönroos,

Pierre Martinez,

Nicholas Matthews,

Grant D. Stewart,

Patrick Tarpey,

Ignacio Varela,

Benjamin Phillimore,

Sharmin Begum,

Neil Q. McDonald,

Adam Butler,

David Jones,

Keiran Raine,

Calli Latimer,

Cláudio R. Santos,

Mahrokh Nohadani,

Aron C. Eklund,

Bradley SpencerDene,

Graham Clark,

Lisa Pickering,

Gordon Stamp,

Martin Gore,

Zoltán Szállási,

Julian Downward,

P. Andrew Futreal,

Charles Swanton

Publication year - 2012

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1113205

Subject(s) - tumor heterogeneity , adaptation (eye) , genetic heterogeneity , computational biology , personalized medicine , evolutionary biology , biology , genetics , gene , cancer , phenotype , neuroscience

Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

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