Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma | Zendy

Michael A. Postow | Zendy; Margaret K. Callahan | Zendy; Christopher A. Barker | Zendy; Yoshiya Yamada | Zendy; Jianda Yuan | Zendy; Shigehisa Kitano | Zendy; Zhenyu Mu | Zendy; Teresa Rasalan | Zendy; Matthew Adamow | Zendy; Erika Ritter | Zendy; Christine Sedrak | Zendy; Achim A. Jungbluth | Zendy; Ramon Chua | Zendy; Arvin Yang | Zendy; Ruth-Ann Roman | Zendy; Samuel Rosner | Zendy; Brenna Benson | Zendy; James P. Allison | Zendy; Alexander M. Lesokhin | Zendy; Sacha Gnjatic | Zendy; Jedd D. Wolchok | Zendy

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Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

Author(s) -

Michael A. Postow,

Margaret K. Callahan,

Christopher A. Barker,

Yoshiya Yamada,

Jianda Yuan,

Shigehisa Kitano,

Zhenyu Mu,

Teresa Rasalan,

Matthew Adamow,

Erika Ritter,

Christine Sedrak,

Achim A. Jungbluth,

Ramon Chua,

Arvin Yang,

Ruth-Ann Roman,

Samuel Rosner,

Brenna Benson,

James P. Allison,

Alexander M. Lesokhin,

Sacha Gnjatic,

Jedd D. Wolchok

Publication year - 2012

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1112824

Subject(s) - ipilimumab , abscopal effect , medicine , melanoma , antigen , immune system , immunology , radiation therapy , cytotoxic t cell , monoclonal antibody , immunotherapy , antibody , cancer research , oncology , biology , biochemistry , in vitro

The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).

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