Open AccessCombination Antifungal Therapy for Cryptococcal Meningitis
Author(s) -
Jeremy Day,
Tran TH Chau,
Marcel Wolbers,
PhuongChi Pham,
Nguyễn Thị Dung,
Anh Nguyen,
Nguyen Hoan Phu,
Ho Dang Trung Nghia,
Nguyen Duy Phong,
Cao Q. Thai,
Le H. Thai,
Ly Van Chuong,
Dinh Xuan Sinh,
Van Anh Duong,
Thu N. Hoang,
Pham Thi Diep,
James Campbell,
Tran Phu Manh Sieu,
Stephen Baker,
Nguyễn Văn Vĩnh Châu,
Tran T. Hien,
David G. Lalloo,
Jeremy Farrar
Publication year - 2013
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1110404
Subject(s) - flucytosine , amphotericin b , medicine , fluconazole , cryptococcal meningitis , antifungal , meningitis , cryptococcosis , amphotericin b deoxycholate , randomized controlled trial , mycosis , combination therapy , cryptococcus , surgery , immunology , microbiology and biotechnology , dermatology , caspofungin , human immunodeficiency virus (hiv) , biology , viral disease
Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days.
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