Origins of theE. coliStrain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany | Zendy

David A. Rasko | Zendy; Dale R. Webster | Zendy; Jason W. Sahl | Zendy; Ali Bashir | Zendy; Nadia Boisen | Zendy; Flemming Scheutz | Zendy; Ellen E. Paxinos | Zendy; Robert Sebra | Zendy; Chen-Shan Chin | Zendy; D Iliopoulos | Zendy; Aaron A. Klammer | Zendy; Paul Peluso | Zendy; Lawrence Lee | Zendy; Andrey Kislyuk | Zendy; James W. Bullard | Zendy; Andrew Kasarskis | Zendy; Susanna Wang | Zendy; John Eid | Zendy; David R. Rank | Zendy; Julia C. Redman | Zendy; Susan R. Steyert | Zendy; Jakob Frimodt-Møller | Zendy; Carsten Struve | Zendy; Andreas Munk Petersen | Zendy; Karen A. Krogfelt | Zendy; James P. Nataro | Zendy; Eric E. Schadt | Zendy; Matthew K. Waldor | Zendy

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Origins of theE. coliStrain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany

Author(s) -

David A. Rasko,

Dale R. Webster,

Jason W. Sahl,

Ali Bashir,

Nadia Boisen,

Flemming Scheutz,

Ellen E. Paxinos,

Robert Sebra,

Chen-Shan Chin,

D Iliopoulos,

Aaron A. Klammer,

Paul Peluso,

Lawrence Lee,

Andrey Kislyuk,

James W. Bullard,

Andrew Kasarskis,

Susanna Wang,

John Eid,

David R. Rank,

Julia C. Redman,

Susan R. Steyert,

Jakob Frimodt-Møller,

Carsten Struve,

Andreas Munk Petersen,

Karen A. Krogfelt,

James P. Nataro,

Eric E. Schadt,

Matthew K. Waldor

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1106920

Subject(s) - outbreak , shiga toxin , serotype , microbiology and biotechnology , escherichia coli , diarrhea , medicine , virulence , enteroaggregative escherichia coli , virology , strain (injury) , biology , enterobacteriaceae , genetics , gene

A large outbreak of diarrhea and the hemolytic-uremic syndrome caused by an unusual serotype of Shiga-toxin-producing Escherichia coli (O104:H4) began in Germany in May 2011. As of July 22, a large number of cases of diarrhea caused by Shiga-toxin-producing E. coli have been reported--3167 without the hemolytic-uremic syndrome (16 deaths) and 908 with the hemolytic-uremic syndrome (34 deaths)--indicating that this strain is notably more virulent than most of the Shiga-toxin-producing E. coli strains. Preliminary genetic characterization of the outbreak strain suggested that, unlike most of these strains, it should be classified within the enteroaggregative pathotype of E. coli.

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