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Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease
Author(s) -
Robert Howard,
Rupert McShane,
James Lindesay,
Craig Ritchie,
Ashley Baldwin,
Robert Barber,
Alistair Burns,
Tom Dening,
David M. Findlay,
Clive Holmes,
Alan Hughes,
Robin Jacoby,
Rob Jones,
Roy Jones,
Ian G. McKeith,
Ajay Macharouthu,
John T. O’Brien,
Peter Passmore,
Bart Sheehan,
Edmund Juszczak,
Cornelius Katona,
Robert K. Hills,
Martín Knapp,
Clive Ballard,
Richard G. Brown,
Sube Banerjee,
Caroline Onions,
Mary Griffin,
Jessica Adams,
Richard Gray,
Tony Johnson,
Peter Bentham,
Patrick Phillips
Publication year - 2012
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1106668
Subject(s) - donepezil , memantine , medicine , placebo , alzheimer's disease , dementia , disease , pathology , alternative medicine
Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease.

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