Breast-Cancer Adjuvant Therapy with Zoledronic Acid
Author(s) -
Robert E. Coleman,
Helen Marshall,
David Cameron,
David Dodwell,
Roger Burkinshaw,
Maccon Keane,
Miguel GilGil,
Stephen Houston,
Robert Grieve,
Peter BarrettLee,
Diana Ritchie,
Julia Pugh,
Claire Gaunt,
Una Rea,
Jennifer Peterson,
Claire Davies,
Victoria Hiley,
Walter M. Gregory,
Richard H. Bell
Publication year - 2011
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1105195
Subject(s) - zoledronic acid , medicine , hazard ratio , adjuvant therapy , breast cancer , adjuvant , clinical endpoint , confidence interval , surgery , oncology , cancer , randomized controlled trial
Data suggest that the adjuvant use of bisphosphonates reduces rates of recurrence and death in patients with early-stage breast cancer. We conducted a study to determine whether treatment with zoledronic acid, in addition to standard adjuvant therapy, would improve disease outcomes in such patients.
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