Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema | Zendy

Stefanie Eyerich | Zendy; Anna Theresa Onken | Zendy; Stephan Weidinger | Zendy; André Franke | Zendy; Francesca Nasorri | Zendy; Davide Pennino | Zendy; Martine Grosber | Zendy; Florian Pfab | Zendy; Carsten B. SchmidtWeber | Zendy; Martin Mempel | Zendy; Ruediger Hein | Zendy; Johannes Ring | Zendy; Andrea Cavani | Zendy; Kilian Eyerich | Zendy

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Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

Author(s) -

Stefanie Eyerich,

Anna Theresa Onken,

Stephan Weidinger,

André Franke,

Francesca Nasorri,

Davide Pennino,

Martine Grosber,

Florian Pfab,

Carsten B. SchmidtWeber,

Martin Mempel,

Ruediger Hein,

Johannes Ring,

Andrea Cavani,

Kilian Eyerich

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1104200

Subject(s) - medicine , antagonism , psoriasis , dermatology , immunology , receptor

The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema. (Supported by the German Research Foundation and others.)

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