Horse versus Rabbit Antithymocyte Globulin in Acquired Aplastic Anemia | Zendy

Phillip Scheinberg | Zendy; Olga Núñez | Zendy; Barbara Weinstein | Zendy; Priscila Scheinberg | Zendy; Angélique Biancotto | Zendy; Colin O. Wu | Zendy; Neal S. Young | Zendy

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Horse versus Rabbit Antithymocyte Globulin in Acquired Aplastic Anemia

Author(s) -

Phillip Scheinberg,

Olga Núñez,

Barbara Weinstein,

Priscila Scheinberg,

Angélique Biancotto,

Colin O. Wu,

Neal S. Young

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1103975

Subject(s) - medicine , horse , aplastic anemia , globulin , gastroenterology , confidence interval , transplantation , hematopoietic stem cell transplantation , anemia , immunology , bone marrow , surgery , biology , paleontology

In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more potent in depleting peripheral-blood lymphocytes and is preferred in other clinical circumstances.

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