A Functional Element Necessary for Fetal Hemoglobin Silencing | Zendy

Vijay G. Sankaran | Zendy; Jian Xu | Zendy; Rachel Byron | Zendy; Harvey A. Greisman | Zendy; Chris Fisher | Zendy; D. J. Weatherall | Zendy; Daniel E. Sabath | Zendy; Mark Groudine | Zendy; Stuart H. Orkin | Zendy; Anuja Premawardhena | Zendy; M. A. Bender | Zendy

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A Functional Element Necessary for Fetal Hemoglobin Silencing

Author(s) -

Vijay G. Sankaran,

Jian Xu,

Rachel Byron,

Harvey A. Greisman,

Chris Fisher,

D. J. Weatherall,

Daniel E. Sabath,

Mark Groudine,

Stuart H. Orkin,

Anuja Premawardhena,

M. A. Bender

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1103070

Subject(s) - intergenic region , biology , locus (genetics) , gene silencing , genetics , chromatin , globin , fetal hemoglobin , regulatory sequence , gene , breakpoint , chromatin immunoprecipitation , microbiology and biotechnology , regulation of gene expression , promoter , gene expression , fetus , genome , pregnancy , chromosomal translocation

An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of targeted therapeutic approaches for fetal hemoglobin induction in the β-hemoglobinopathies. Although recent studies have uncovered trans-acting factors necessary for this regulation, limited insight has been gained into the cis-regulatory elements involved.

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