Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers | Zendy

Alireza HeraviMoussavi | Zendy; Michael S. Anglesio | Zendy; S.W. Grace Cheng | Zendy; Janine Senz | Zendy; Winnie Yang | Zendy; Leah Prentice | Zendy; Anthony P. Fejes | Zendy; Christine Chow | Zendy; Alicia Tone | Zendy; Steve E. Kalloger | Zendy; Nancy Hamel | Zendy; Andrew Roth | Zendy; Gavin Ha | Zendy; Adrian Wan | Zendy; Sarah MainesBandiera | Zendy; Clara Salamanca | Zendy; Barbara Pasini | Zendy; Blaise Clarke | Zendy; Anna F. Lee | Zendy; ChengHan Lee | Zendy; Chengquan Zhao | Zendy; Robert H. Young | Zendy; Samuel Aparício | Zendy; Poul H. Sorensen | Zendy; Michelle M.M. Woo | Zendy; Niki Boyd | Zendy; Steven J.M. Jones | Zendy; Martin Hirst | Zendy; Marco A. Marra | Zendy; C. Blake Gilks | Zendy; Sohrab P. Shah | Zendy; William D. Foulkes | Zendy; Gregg B. Morin | Zendy; David G. Huntsman | Zendy

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Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

Author(s) -

Alireza HeraviMoussavi,

Michael S. Anglesio,

S.W. Grace Cheng,

Janine Senz,

Winnie Yang,

Leah Prentice,

Anthony P. Fejes,

Christine Chow,

Alicia Tone,

Steve E. Kalloger,

Nancy Hamel,

Andrew Roth,

Gavin Ha,

Adrian Wan,

Sarah MainesBandiera,

Clara Salamanca,

Barbara Pasini,

Blaise Clarke,

Anna F. Lee,

ChengHan Lee,

Chengquan Zhao,

Robert H. Young,

Samuel Aparício,

Poul H. Sorensen,

Michelle M.M. Woo,

Niki Boyd,

Steven J.M. Jones,

Martin Hirst,

Marco A. Marra,

C. Blake Gilks,

Sohrab P. Shah,

William D. Foulkes,

Gregg B. Morin,

David G. Huntsman

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1102903

Subject(s) - germline , germline mutation , cancer research , somatic cell , missense mutation , germ cell tumors , biology , mutation , rnase p , genetics , microbiology and biotechnology , gene , rna , chemotherapy

Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors.

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