Inflammatory Cortical Demyelination in Early Multiple Sclerosis | Zendy

Claudia F. Lucchinetti | Zendy; Bogdan F. Popescu | Zendy; Reem F. Bunyan | Zendy; Natalia Moll | Zendy; Shanu F. Roemer | Zendy; Hans Lassmann | Zendy; Wolfgang Brück | Zendy; Joseph E. Parisi | Zendy; Bernd W. Scheithauer | Zendy; Caterina Giannini | Zendy; Stephen D. Weigand | Zendy; Jay Mandrekar | Zendy; Richard M. Ransohoff | Zendy

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Inflammatory Cortical Demyelination in Early Multiple Sclerosis

Author(s) -

Claudia F. Lucchinetti,

Bogdan F. Popescu,

Reem F. Bunyan,

Natalia Moll,

Shanu F. Roemer,

Hans Lassmann,

Wolfgang Brück,

Joseph E. Parisi,

Bernd W. Scheithauer,

Caterina Giannini,

Stephen D. Weigand,

Jay Mandrekar,

Richard M. Ransohoff

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1100648

Subject(s) - medicine , multiple sclerosis , pathology , brain biopsy , magnetic resonance imaging , white matter , cortex (anatomy) , hyperintensity , autopsy , biopsy , radiology , immunology , neuroscience , biology

Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonance imaging studies indicate that cortical damage occurs early in the disease.

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