Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis | Zendy

Francis X. McCormack | Zendy; Yoshikazu Inoue | Zendy; Joel Moss | Zendy; L.G. Singer | Zendy; Charlie Strange | Zendy; Koh Nakata | Zendy; Alan F. Barker | Zendy; Jeffrey T. Chapman | Zendy; Mark Brantly | Zendy; James Stocks | Zendy; Kevin K. Brown | Zendy; Joseph P. Lynch | Zendy; Hilary J. Goldberg | Zendy; Lisa R. Young | Zendy; Brent W. Kinder | Zendy; Gregory P. Downey | Zendy; Eugene J. Sullivan | Zendy; Thomas V. Colby | Zendy; Roy T. McKay | Zendy; Marsha M. Cohen | Zendy; Leslie Korbee | Zendy; Angelo M. TaveiraDaSilva | Zendy; Hye Seung Lee | Zendy; Jeffrey P. Krischer | Zendy; Bruce C. Trapnell | Zendy

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Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

Author(s) -

Francis X. McCormack,

Yoshikazu Inoue,

Joel Moss,

L.G. Singer,

Charlie Strange,

Koh Nakata,

Alan F. Barker,

Jeffrey T. Chapman,

Mark Brantly,

James Stocks,

Kevin K. Brown,

Joseph P. Lynch,

Hilary J. Goldberg,

Lisa R. Young,

Brent W. Kinder,

Gregory P. Downey,

Eugene J. Sullivan,

Thomas V. Colby,

Roy T. McKay,

Marsha M. Cohen,

Leslie Korbee,

Angelo M. TaveiraDaSilva,

Hye Seung Lee,

Jeffrey P. Krischer,

Bruce C. Trapnell

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1100391

Subject(s) - lymphangioleiomyomatosis , sirolimus , medicine , placebo , lung , urology , vital capacity , discontinuation , gastroenterology , diffusing capacity , lung function , pathology , alternative medicine

Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) signaling, which regulates cellular growth and lymphangiogenesis. Sirolimus (also called rapamycin) inhibits mTOR and has shown promise in phase 1-2 trials involving patients with LAM.

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