HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans | Zendy

Mark McCormack | Zendy; Ana Alfirevic | Zendy; Stéphane Bourgeois | Zendy; John Farrell | Zendy; Dalia Kasperavičiūtė | Zendy; Mary Carrington | Zendy; Graeme J. Sills | Zendy; Anthony G Marson | Zendy; Xiaoming Jia | Zendy; Paul I. W. de Bakker | Zendy; Krishna Chinthapalli | Zendy; Mariam Molokhia | Zendy; Michael Johnson | Zendy; Gerard D. O’Connor | Zendy; Elijah Chaila | Zendy; Saud Alhusaini | Zendy; Kevin V. Shianna | Zendy; Rodney A. Radtke | Zendy; Erin L. Heinzen | Zendy; Sophie Nicole | Zendy; Massimo Pandolfo | Zendy; Werner J. Pichler | Zendy; B. Kevin Park | Zendy; Chantal Depondt | Zendy; Sanjay M. Sisodiya | Zendy; David B. Goldstein | Zendy; Panos Deloukas | Zendy; Norman Delanty | Zendy; Gianpiero L. Cavalleri | Zendy; Munir Pirmohamed | Zendy

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HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

Author(s) -

Mark McCormack,

Ana Alfirevic,

Stéphane Bourgeois,

John Farrell,

Dalia Kasperavičiūtė,

Mary Carrington,

Graeme J. Sills,

Anthony G Marson,

Xiaoming Jia,

Paul I. W. de Bakker,

Krishna Chinthapalli,

Mariam Molokhia,

Michael Johnson,

Gerard D. O’Connor,

Elijah Chaila,

Saud Alhusaini,

Kevin V. Shianna,

Rodney A. Radtke,

Erin L. Heinzen,

Sophie Nicole,

Massimo Pandolfo,

Werner J. Pichler,

B. Kevin Park,

Chantal Depondt,

Sanjay M. Sisodiya,

David B. Goldstein,

Panos Deloukas,

Norman Delanty,

Gianpiero L. Cavalleri,

Munir Pirmohamed

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1013297

Subject(s) - carbamazepine , odds ratio , medicine , allele , toxic epidermal necrolysis , human leukocyte antigen , immunology , genotyping , dermatology , genotype , genetics , epilepsy , biology , antigen , gene , psychiatry

Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations.

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